POSIMIR is manufactured with the SABER
Platform Technology, enabling instant and sustained delivery of bupivacaine2

  • Fully resorbable, sucrose-based, organic matrix2
  • Allows for a controlled rate of bupivacaine release continuously through 72 hours, avoiding early dose dumping2
  • Provides a sustained release rate of 10 mg/h, consistent with wound infusion catheters found to be effective in producing postsurgical analgesia2

RELEASE OF BUPIVACAINE BASE FROM POSIMIR2

Deconvolution analysis of PK samples from
5 healthy volunteers administered POSIMIR 5 mL
via abdominal subcutaneous trailing injection2

0 12 40 30 20 10 0 24 36 Time, h Infusion pump rate Mean (+SD) release rate, mg/h 48 60 72 bupivacaine base

REQUEST A REPRESENTATIVE

A representative can discuss POSIMIR with you to review
administration instructions and respond to your questions.

INDICATIONS AND USAGE

POSIMIR is a bupivacaine solution indicated in adults for administration into the subacromial space under direct arthroscopic visualization to produce post-surgical analgesia for up to 72 hours following arthroscopic subacromial decompression.

IMPORTANT SAFETY INFORMATION

BOXED WARNING: RISK OF POTENTIAL ADVERSE EMBOLIC EFFECTS RESULTING FROM INADVERTENT INTRAVASCULAR INJECTION.